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KMID : 0359319890290020099
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Korean Journal of Veterinary Research
1989 Volume.29 No. 2 p.99 ~ p.104
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Physiological characteristics of histamine receptor of the isolated renal artery in dog
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Abstract
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To elucidate the physiological characteristics of histamine receptor of the isolated renal artery in dog, effects of various receptor blockers and Ca++ channel blockers on the contractile responses of histamine were investigated in the isolated renal artery of dog.
The results were summarized as follows:
1. Histamine caused the contraction in the isolated renal artery of dog, and the contractile responses increased between the concentration of 5×10^(-6)M and 10^(-2)M in dose-dependent manner.
2. The contractile response induced by histamine (10^(-3)M) was not blocked by pretreatment with atropine (10^(-6)M), phentolamine (10^(-6)M), propranolol (10^(-6)M) or cimetidine (10^(-6)M), but was completely blocked by pretreatment with pyrilamine (10^(-6)M).
3. The contractility induced by histamine (10^(-3)M) was decreased in the Ca++ free medium.
4. The contractile response induced by histamine (10^(-3)M) was markedly inhibited by pretreatment with papaverine (5×10^(-5)M) or verapamil (5×10^(-5)M).
5. After the pre-contraction induced by norepinephrine (10^(-7)M) or prostaglandin F2α (5×10^(-6)M), the contractile response induced by the additional treatment of histamine (10^(-3)M) was markedly increased compared with that of histamine (10^(-3)M) alone.
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